Background
Glucose enters the cell membrane by facilitated movement via the Glucose transporter 2 (GLUT2), also known as SLC2A2. The figure describes the intracellulat process of glycolysis and how it is regulated.
Your Mission
Draw the part of the pathway outlined in red below:
- Add a metabolite node for "Glucose-6-phosphate".
- Connect the glucose node to Glucose-6-phosphate with a mim-conversion interaction.
- Add an anchor to the interaction and connect the enzyme (GCK) and inhiibitor (GCKR) with mim-catalysis and mim-inhibition interactions, respectively.
- Connect Glucose-6-phosphate with Pyruvate using a mim-conversion interaction.
- Update the text label for the node with ChEBI ID 57288 (Acetyl-CoA) node to "Acetyl-CoA". Repeat for the node with ChEBI ID 57384 (Malonyl-CoA), updating the label to "Malonyl-CoA".
- Connect Pyruvate with Acetyl-CoA using a mim-conversion interaction.
- Update the text label for the node with ChEBI ID 26607 (SFA) node to "Saturated Fatty Acid". Repeat for the node with ChEBI ID 25413 (MUFA), updating the label to "Monounsaturated fatty acid". Adjust the size of the nodes to accomodate the longer label.
- Group the ACACA and ACACB nodes.
- Complete the remaining steps in the smae way, adding mim-conversion interactions and enzymes.
- Save your work as a GPML file under File > Save As.
- Drag-and-drop the GPML file below to check if it is correct.